Metaphysical Poetry Essay

In the view of some critics, poems of this period have ‘delighted, puzzled and alienated readers’. What do you consider to be the demands and rewards for the readers of Metaphysical poetry? Refer in detail to at least three poems from this section of the anthology. You should consider the argument of the poems and the poet’s choices of language and verse form. Metaphysical poetry bases its ideas on explaining an extended metaphor, often on important and intellectual subjects such as the transience of life, mans relationship with God and love, in a context that entertains readers rather than boring them. This extended metaphor is known as the metaphysical conceit. It is often subtle, and therefore to some readers can be overlooked. However, for the readers who are able to uncover it, it can provide a deeper insight into the true meaning of the poem and can also make them question their own views on the subject, this is the reward intellectual readers receive from reading metaphysical poetry. Metaphysical poetry is often directed at intellectual readers. Some phrases in the poems would require prior knowledge to understand. This means that not all readers would be able to grasp the true meaning of the poem, or would overlook phrases. For example, in To His Coy Mistress Marvell uses several biblical references, such as ‘I would love you ten years before the flood’. This refers to Noah’s ark, and the flood depicted in the Bible. By using this image he is expressing that he would love her ten years before the beginning of time, and this is a subtle but strong compliment to his love. He also uses another biblical reference, ‘And you should, if you please, refuse Till the conversion of the Jews’. Those with prior knowledge would understand the idea that the Jews will never convert. The speaker in the poem is saying that she could refuse him forever and he would still love her. A reader who does not have biblical knowledge would surely overlook these phrases, but a reader who understands the strong compliments in this statements would have a much more enjoyable read of the poem, and would discover an extra level of meaning. This is one of the rewards of reading and understanding Metaphysical poetry. The idea of religion works in metaphysical poetry more than just in references to create subtle ideas. Religion is a common topic in Metaphysical poetry. Poems such as Love by George Herbert are based entirely around religion. In this poem, the speaker describes his interaction with God. This image of God is also personified as Love, and may suggest that God is love. Again, some readers may overlook this, and not realise that the person described in the poem is actually God. The way we can see that this figure is God is due to the use of lexis from the semantic field of religion. Words such as ‘sin’, ‘soul’, ‘Lord’ and ‘serve’ are all present, and this lexis is common in religious literature. The idea of religion works both ways, however. In To His Coy Mistress, although there is some reference to religion – as discussed earlier – there are also several phrases that don’t give an image of religion. The phrases ‘deserts of vast eternity’ is used to describe the afterlife, and this is an image that many Christians would not believe to be the afterlife. Marvell is suggesting a different view from the idea that everyone will go to either Heaven or Hell, an advanced view for a man living in an extremely religious time. One major device metaphysical poets use is the idea of a metaphysical conceit. All the metaphysical poems uses a metaphor to compare dissimilar things. For example, in Robert Herrick’s To Daffodils people are likened to daffodils, in relation to the transience of life. He uses phrases such as ‘haste away so soon’, and ‘We have short time to stay as you’. He is saying that, like daffodils, people will die too. This is a strange concept, but as you read the poem you begin to understand his logic. It would take a sophisticated mind to understand the ideas Herrick presents, but those who do understand would receive a deeper understanding of his argument. Structurally, Metaphysical poets use structure to present ideas in a clear and logical fashion. The ideas are often complex, and so, like an essay about a complicated topic, structure helps the reader understand. One common form of structure is to separate the poem into parts, each with an argument that leads to a clear conclusion. In To His Coy Mistress Marvell separates his argument into three parts. In the first part he describes what he would do if he had all the time in the world, how he would ‘adore each breast’ for two hundred years. However, in the second part he describes how he does not have that amount of time to adore her, and that she would die long before, and ‘worms shall try that long-preserved virginity’. In the final part Marvell concludes that as he does not have the time to adore her how he wishes, she should yield to his passion. This is a developed argument in three parts, and is a form of syllogism. It helps the reader understand the intent of the poem in a similar way to using paragraphs would in an essay. Rhythm is also used in metaphysical poetry to express the writers values. In To Daffodils the writer is presented as a person who has an unusual lack of trepidation for death. The opening quatrain is written in a mixture of iambic tetrameter and trimeter. This gives it a childish and nursery rhyme like rhythm. This helps to show the reader how the writer is uncaring about the situation, and is almost nonchalant about death. The line ‘stay, stay’, puts a halt to the childlike rhyme, but in a way could be perceived to make the first stanza sound almost like a lullaby. This makes the poem seem very calm and simple, feelings not usually associated with death and the transience of life. Feeling the effects of this rhythm show the reader the true feelings of the writer in a way many would not see. In conclusion, the metaphysical poets used many different devices to hide away many of the main ideas of their poems. Whilst many readers can understand the basic idea of the poem, they will not gain a full understanding of the point the poet is trying to make unless they have the knowledge and understanding required of a reader of Metaphysical poetry. For this reason, many will feel puzzled and alienated, whilst others will be truly delighted once they have gained the deeper understanding.

Formalism vs Substantivism

The Disembedded economy Why might Polanyi claim that disembedded economies are less stable than embedded ones? Does a market society require a certain level of insecurity for its members? How might people find a disembedded economy empowering? Can there be such a thing as a ‘pure’ market society? Is ‘marketization’ a helpful concept with which to understand contemporary capitalism? Industrial capitalism and machines etc were all part of the establishment of the market economy. The motive of subsistence must become one of gain. The merchant makes his profits on the market and prices are allowed to regulate themselves.Such a self-regulating system of markets is what we call a market economy. The transformation to this system is like the metamorphis of a caterpillar- so stark that it is almost not like a continuous process. Machines in a society transform nature into a commodity. Dalton on Polanyi: Material self-gain is institutionally enforced In traditional b ands the institutions through which goods were produced and distributed wer embedded in an inseperable part of social institutions, and the economy functioned as by product of kinship political and religious obligations and relationships. economy’ is not a field of experience of which humans have always been aware. Primitive societies are gemeinchaften not gesellshaften. Hunger is not an incentive for production. Classical economics and Marxist socialism came from the industrial revolution. Laissez faire capitalism was created in response to the need for machine technology Burling Economics deals with the material means to man’s existence: Does the good have to be ‘material’ in order to be in the realm of economic? Price of a ticket or the cost of someone’s wages are not material yet are economic.We economize between material and non material ends. Do I work overtime in order to afford myself a DVD or do I refuse the overtime and have more leisure t ime at home with my family? Polanyi makes the distinction between economics in the substantive sense that’s material, and in the formal sense- rationalizing and calculating. Polanyi says that because we have the market these two aspects come together but they wouldn’t in a primitive economy. Primitives economize too. The materialness is irrelevant.Economics is the distribution of goods and services: But not any goods and services, only economic ones†¦ which makes this statement useless. If its to do with price systems then some societies don’t have economics. ‘Economics is the allocation of scarce means to multiple ends’ Draws parralells with Freud and maximizing by sacrificing pleasure for future gain. We need to escape the notion of economic as involved with the material , in order to move on with the discussions. Cook ‘Love distorts indeed, but hate distorts even more’Substantivist theory built around the market and pre-market s ocieties. Now the pre-market societies are almost extinct. Dalton- the section being dominated by the market principle is becoming enlarged. Bohannan- transitional and peasant economies are mentioned. Frank knight and merville herskovitz debate- herskovitz didn’t understand the economic man. Romantic anti-market syndrome Polanyi-primitive societies, reciprocity and redistribution- alledgedly a conflict-free model. Le Clair- why is there a felt need for a substantivist definition of economics.Polanyi and Dalton- scarcity is solely a function of social organization Anti market ideology. Go against the scientific method of enquiry- test and dismiss Dalton Economic theory cannot be applied to primitive economies Economic theory was influenced by factory industrialism and market organization. The market continues outside of market places in the west It is market organization that compels its participants to seek material self-gain: each must sell something of market value to acqui re the material means of existence.Back in the 19th century the economy was a cohesive entity apart from other subsystems in society. Neither government, family or religion controlled market organization. They did obviously affect supply and demand though (eg more fish in catholic countries). When market organization is economy wide it creates a market society in the sense that social organization has to adapt to market needs to allow the sustained provision of material goods and of money incomes with which to acquire goods. A market economy can only exist in a market society†¦ society itself is subordinated to the laws of the market’- Polanyi (e. g when labourers wages drop they look for work elsewhere and migrate, so location of population conforms to market registered needs for labour) The market economy is highly decentralized, and this reinforces the atomistic view of society as simply an aggregate of self-interested individuals. William Townsend- hunger makes peopl e workMalthus- natural fertility of humans makes food scarce and population growth brought about wages. Man’s existence requires material sustenance, but not unlimited wants, this is product of social organization. Economic in the substantive sense ‘provision of material goods which satisfy biological and social wants’. Economic in the formalist sense is described by the terms ‘economical’ and ‘economizing’. Denotes a set of rules designed to maximize the achievement of some end or to minimize the expenditure of some means.Substantivists believe that all places have an economy, but formalists believe that all places economize. In primitive economies people do not want profit. Where money is used in a primitive economy, it is not all-purpose money. -cattle/bridewealth. Market economy is unicentric because of the wide variety of material items and labour transacted in the sphere of market exchange. In contrast, primitive economy is multice ntric and the dominant centres are organized through nonmarket patterns of intergration such as reciprocity and redistribution.What is a money economy to an anthropologist appears as a market economy to an economist. In primitive economy the basic institutional precondition is absent, the bulk of material income is not derived from, and therefore does not depend on market sales of output. Firth in NG-There is no final measure of the value of individual things, and you can’t make everything have a value in relation to one thing as there are many types of exchange.In primitive societies there are no penalties for non-repayment of loans. Primitive economy is different from market industrialism not in degree but in kind. Cancian Considers the two sides of the argument Formalists- even if a man is maximizing using only the scarcity of his human energy it is still maximizing. So he is economizing. It’s wrong to reject the strategy before trying to balance the equation. Burli ng-economic anthropology should be the search for the multiple actors that people maximize. t

Calcium carbonate

Calcium carbonate Essay Outline1 4.1INTRODUCTION2 4.2AIMS AND OBJECTIVES3 Chapter 24 5.THEORY A ; METHOLOGY5 5.1PRINCIPLE OF THE EXPERIMENT6 5.2APPARATUS AND EQUIPMENTS7 Mortar and pestle Conical flasksWhite tile8 Filter funnelFiltter paper25.00 cm3 pipette9 5.3CHEMICAL USED10 2 M HCl Phenolphthalein11 2 M NaOH12 5.4PROCEDURE13 Chapter 314 6.EXPERIMENTAL Consequence15 6.1THE COLOR CHANGE OF THE SOLUTION16 6.2THE TITRATION RESULT OF BROWN EGG17 6.3THE TITRATION RESULT OF WHITE EGG18 119 220 321 Volume of eggshells solution/cm322 25.0023 25.0024 25.0025 Volume of NaOH used/cm326 20.4027 20.3528 20.0029 Chapter 430 7.CLCULATIONS31 7.1CALCULATIONS32 7.1.1 FOR BROWN EGG33 7.1.2 FOR WHITE EGG34 Chapter 535 8.DISCUSSION AND CONCLUTION36 8.1CONCLUSION37 8.2DISCUSSION38 Beginning of mistakes39 9. Reference 4.1INTRODUCTION Calcium carbonate, CaCO3, is found in nature giving hardness and strength to things such as seashells, stones, and eggshells. Equally difficult as this substance is, it will respond readily with hydrochloric acid to give C dioxide gas ( and two other merchandises ) . In this experiment pupils will plan an experiment by responding eggshells with 2 M HCl to compare the Ca carbonate composing of white ( poulet ) eggshells to brown eggshells. A good quality eggshell will incorporate, on norm, 2.2 gms of Ca in the signifier of Ca carbonate. Approximately 94 % of a dry eggshell is calcium carbonate and has a typical mass of 5.5 grams,1 although these values can differ depending on beginnings. Sums every bit low as 78 % have been published. The staying mass is composed mostly of P and Mg, and hint sums of Na, K, Zn, manganese, Fe, and Cu. In the instance of brown versus white eggs, a unequivocal difference in Ca carbonate sums may be difficult to bring out. However, see this. The colour of the eggs is nil more than a consequence of a different strain. The quality, nutritionary value, and gustatory sensation are indistinguishable between white and brown eggs, though two noteworthy differences are size and monetary value. Brown eggs are normally larger and somewhat more expensive. The ground for the monetary value addition is because brown eggs come from larger biddies, which need to be fed more nutrient daily. With a larger c onsumption of Ca each twenty-four hours, one might anticipate the produced egg to hold a higher Ca carbonate content. However, since the eggs are larger, it must be kept in head that the Ca is spread over a larger surface country during egg formation. A brown eggshell s increased inclination to interrupt, when compared to white, is frequently attributed to this â€Å"thinning out† of Ca during deposition. To avoid the breakage of eggs before making market, the eggshells needs to be every bit strong as possible. The strength of eggshells is chiefly determined by the per centum of Ca carbonate in it. In order to supervise the quality of eggshells, the undermentioned experiment has to be done to find the per centum of Ca carbonate in eggshells.In this experiment, back titration is used. First, extra acid is reacted with the Ca carbonate in eggshells. 2HCl ( aq ) +CaCO3 ( s ) >CaCl2 ( aq ) +H2O ( cubic decimeter ) +CO2 ( g ) Subsequently, if we can happen out the figure of mole of unreacted acid, figure of mole of Ca carbonate can so be found out. The figure of mole of unreacted acid can be found by titration with the undermentioned reaction. HCl ( aq ) +NaOH ( aq ) >H2O ( cubic decimeter ) +NaCl ( aq ) Percentage by mass of Ca carbonate in eggshell can so be calculated by the undermentioned expression: 4.2AIMS AND OBJECTIVES The intent of this experiment is to find the per centum by mass of Ca carbonate in eggshells. READ: I would remind you that extremism in the defense o Essaydesign an experiment that quantifies the sum of Ca carbonate nowadays in a natural substance. associate the sum of a reactant or merchandise of a chemical reaction to another reactant or merchandise. work collaboratively with their equals to work out a given job in the research lab in a manner that theoretical accounts the scientific method. use a common acid reaction between hydrochloric acid and the carbonate ion. Chapter 2 5.THEORY A ; METHOLOGY 5.1PRINCIPLE OF THE EXPERIMENT During this experiment, the per centum of CaCO3 in an eggshell is determined by responding the eggshell with hydrochloric acid. The equation for this reaction is: 2HCl ( aq ) + CaCO3 ( s ) >Ca2+ ( aq ) + CO2 ( g ) + H2O ( cubic decimeter ) + 2Cl- ( aq ) This reaction can non be used straight titrate with the CaCO3. Alternatively, an surplus of hydrochloric acid is added to fade out the eggshell, and the staying acid is titrated with NaOH solution to find the sum of acid that did non respond with the eggshell. The equation used to find the sum of remnant acid is: HCl ( aq ) + NaOH ( aq ) > H2O ( cubic decimeter ) + Na+ ( aq ) + Cl- ( aq ) 5.2APPARATUS AND EQUIPMENTS eaker Pipette FillerElectronicbalance Volumetric flaskBuretteWash bottle Mortar and pestle Conical flasksWhite tile Filter funnelFiltter paper25.00 cm3 pipette 5.3CHEMICAL USED 2 M HCl Phenolphthalein 2 M NaOH 5.4PROCEDURE White and Red coloring material eggshells have taken and the protein membrane was removed on the interior of the eggshells. The eggshell was washed with distilled H2O Dried in an oven for few proceedingss. The eggshell was so grounded into all right pulverization by howitzer and stamp. 2g of eggshell pulverization is weighted accurately by utilizing an electronic balance and it was transferred to a conelike flask. 25.00 cm3 of HCl was pipetted to fade out the eggshell pulverization. Distilled H2O was added to the flask until it reached about 100cm3. The flask was swirled gently. Put the solution into cubed for two yearss. Faltered the solution utilizing filter documents. Pippet out 25.00 cm3 from each solutions to titration flasks. The solution was so titrated with standardised NaOH. Repeat another two samples from each solution. Roll up the right burette readings at the terminal point. Chapter 3 6.EXPERIMENTAL Consequence 6.1THE COLOR CHANGE OF THE SOLUTION White egg Brown egg Colourless pink Colourless pink 6.2THE TITRATION RESULT OF BROWN EGG 1 2 3 Volume of eggshells solution/cm3 25.00 25.00 25.00 Volume of NaOH used/cm3 20.10 19.90 20.10 Average volume of NaOH used: ( 20.10+19.90+20.10 ) = 20.03cm33 6.3THE TITRATION RESULT OF WHITE EGG 1 2 3 Volume of eggshells solution/cm3 25.00 25.00 25.00 Volume of NaOH used/cm3 20.40 20.35 20.00 *Average volume of NaOH used: ( 20.40+20.35+20.00 ) =20.25cm33 Chapter 4 7.CLCULATIONS 7.1CALCULATIONS 2HCl ( aq ) + CaCO3 ( s ) >Ca2+ ( aq ) + CO2 ( g ) + H2O ( cubic decimeter ) + 2Cl- ( aq ) HCl ( aq ) + NaOH ( aq ) > H2O ( cubic decimeter ) + Na+ ( aq ) + Cl- ( aq ) 7.1.1 FOR BROWN EGG Number of moles of NaOH used to respond with HCl =20.03cm3 /1000 ) X2M = 40.06X 10-3 mol Since figure of moles of NaOH = figure of moles of HCl in 25cm3 =40.06 X 10-3 mol HCl mols in 100cm3 = 40.06 Ten 10-3 Ten 4 mol The initial no of moles of HCl: volume X molar concentration = 100/1000 X2M = 200X10-3 mol Number of moles of HCl used to respond with CaCO3 = ( 200X10-3 160.24X 10-3 ) mol = 39.76X10-3 mol Harmonizing to the equation, one mole of HCI required to respond with 2 moles of CaCO3, Number of moles of CaCO3 reacted =39.76X10- 3 /2 = 19.88X10-3 mol The weight of CaCO3 = 19.88X10-3g X100g The % of CaCO3 in eggshell ( brown ) = ( 1.988/2 ) X100 % =99.4 % 7.1.2 FOR WHITE EGG Number of moles of NaOH used to respond with HCl: ( 20.25cm3/1000 ) X2 = 40.50X10-3mol Since figure of moles of NaOH=number of moles of HCl in 25cm3 = 4.50X10-3mol HCl Volume in 100cm3 = 40.50 X10-3 X4 mol The initial moles of HCl: volume X molar concentration = 100/1000 X2M = 200X10-3 mol Number of moles of HCl used to respond with CaCO3: ( 200X10-3 162X10-3 ) mol = 38X10-3 mol Number of moles of CaCO3 reacted =38X10-3/2 = 19X10-3 mol The weight of CaCO3 = 19X10-3g X100 The % of CaCO3 in eggshell ( white ) = ( 1.9/2 ) X100 % =95.0 % Chapter 5 8.DISCUSSION AND CONCLUTION 8.1CONCLUSION Percentage of CaCO3 in ruddy eggshells= 99.4 % Percentage of CaCO3 in white eggshells= 95.0 % Therefore ruddy eggshells has the higher per centum of CaCO3. 8.2DISCUSSION Beginning of mistakes The eggshell pulverization did non fade out wholly Variation in ocular judgement at the terminal point Instrumental mistakes of the electronic balance The eggshell was non to the full dried Some droplets of solution may still adhere on the beaker and the glass rod which lead to the decrease in figure of moles of extra HCl In this Experiment we can besides make the EDTA titration. 9. Reference hypertext transfer protocol: //www.google.lk/search? hl=en A ; source=hp A ; q=caco3+percentage+in+eggshell A ; btnG=Google+Search A ; meta= A ; aq=f A ; oq= hypertext transfer protocol: //wwwchem.csustan.edu/chem1102/Egg.htm hypertext transfer protocol: //www.oppapers.com/essays/Determine-Percentage-Mass-Calcium-Carbonate-Eggshells/165593 hypertext transfer protocol: //ag.ansc.purdue.edu/poultry/multistate/koelkebeck1.htm

A Study on Total Quality Management and Lean Manufacturing Assignment - 1

A Study on Total Quality Management and Lean Manufacturing - Assignment Example These include quality control measures, selecting the best machines for production, maintaining higher levels of security, being potent in project management and proper maintenance of tools and equipments among other strategies. This paper addresses the case evaluation of Toyota and Total quality management by looking at the TQM methodologies and tools, some of the steps that were required in developing TQM at Toyota, how it was implemented at the company, how it worked, TQM criticism and finally how the company responded to the new plan of management. Total Quality management (TQM) is a management structure that mainly intends at improving production standards by using the already existing organs, for example, quality control (Besterfield, 2011). It is organized into four levels; Plan, Do, Check and Act, which is commonly abbreviated as PDCA. At the first level, Plan, there is identification of an issue, could be a challenge or a problem with all the relevant information concerning it not leaving out the problem,s main cause. It then develops further to the Do level where possible solutions are looked into. These further progresses into checking where the concerned parties do data comparison before it moves to the final stage where recommendations to the problems are done (Rawlins, 2008). Toyota motors is one of the companies that has successfully implemented Total Quality Management to ensure high quality products that serves their clients with contentment hence leading to success of the company, including the success of the soc iety. These refer to an accurate system used to justify a state of event or situation, which can be used in data analysis and, in turn, lead to accurate decision-making. Some of the tools and methodologies that are employed by TQM are the management tools, quality control tools and the improvement cycle, which is commonly referred to as PDCA (Besterfield, 2011). In ensuring that the production level at Toyota

Computer Platforms Research Paper Example | Topics and Well Written Essays - 1250 words

Computer Platforms - Research Paper Example A binary input of 0100 would light four LEDs in a row whilst a binary input of 0101 would light five LEDs in a row. Derive the truth-table for a 4 bit input/ 16 bit output decoder which would be used to power this linear display. Solution: Let x1, x2, x3, x4, x5, x6, x7, x8, x9, x10, x11, x12, x13, x14 and x15 represent the linear array of LEDs. Let A, B, C and D represent the binary input terminals. The truth-table for the linear display is shown in Figure 2.2. .. Table 2.1 gives details as to which segments should be energised to display various decimal values at the 4-pin input. Decimal A B C D Segments 0 0 0 0 0 a, b, c, d, e, f 1 0 0 0 1 b, c 2 0 0 1 0 a, b, g, e, d 3 0 0 1 1 a, b, c, d, g 4 0 1 0 0 b, c, f, g 5 0 1 0 1 a, c, d, f, g 6 0 1 1 0 c, d, e, f, g 7 0 1 1 1 a, b, c 8 1 0 0 0 a, b, c, d, e, f, g 9 1 0 0 1 a, b, c, f, g Table 2.1 Truth-table for BCD-to-seven-segment decoder Hence we can derive expressions for each segment, as follows: a = A'B'C'D' + A'B'CD' + A'B'CD + A'BC'D + A'BCD + AB'C'D' + AB'C'D b = A'B'C'D' + A'B'C'D + A'B'CD' + A'B'CD + A'BC'D' + A'BCD + AB'C'D' + AB'C'D c = A'B'C'D' + A'B'C'D + A'B'CD + A'BC'D' + A'BC'D + A'BCD' + A'BCD + AB'C'D' + AB'C'D d = A'B'C'D' + A'B'CD' + A'B'CD + A'BC'D + A'BCD' + AB'C'D' e = A'B'C'D' + A'B'CD' + A'BCD' + AB'C'D' f = A'B'C'D' + A'BC'D' + A'BC'D + A'BCD' + AB'C'D' + AB'C'D g = A'B'CD' + A'B'CD + A'BC'D' + A'BC'D + A'BCD' + AB'C'D' + AB'C'D 2.b A display composed of a linear array of LEDs, is to respond to a 4-bit binary input which is dependent on the absolute binary value by lighting each successful element. A binary input of 0100 would light four LEDs in a row whilst a binary input of 0101 would light five LEDs in a row. Derive the truth-table for a 4 bit input/ 16 bit output decoder which would be used to power this linear display. Solution: Let x1, x2, x3, x4, x5, x6, x7, x8, x9, x10, x11, x12, x13, x14 and x15 represent the linear array of LEDs. Let A, B, C and D represent the binary input terminals. The truth-table for the linear display is shown in Figure 2.2. Table 2.2 Truth-table for LEDs of linear display 3.a The decimal number 101 may be represented in binary as 01100101. Using One's

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Surveillant assemblages - Essay Example Nowadays in the streets of London, the general public is not too much worried about the effects of CCTV monitoring. Erosion of privacy for the average citizen is not a reality. But for those who widely look towards the social benefits of surveillance, the notion that people are becoming inured to the gaze of the camera in a worrisome matter. Another interesting development in this area is that the authorities have started to equip cameras with loud speakers. This allows human monitors to caution people caught littering or brawling on the street. These types of cameras cannot be ignored like the ordinary cameras but there are critics who say that theses cameras cross the line from prevention of crime into public bullying. According to experts the next generation cameras that are used for surveillance in the streets of London will be equipped wit computer software that can judge suspicious behavior that can lead towards a crime.The London police have started to use this technology very effectively. This same technology is also pursued by the London traffic authorities to track and charge vehicles that enter the congestion zone The city of London has spent nearly 200 million pounds for the installation of CCTV,s in each and every part of the city. The proportion of crimes committed in the city is going up and not down. Cases of solving crimes are vastly going down. Ironically some places where there are more cameras installed have a record of worse crime solving rates. There are now more than 10000 cameras.

Nursing care during Primary Angioplasty Essay Example | Topics and Well Written Essays - 1750 words

Nursing care during Primary Angioplasty - Essay Example Details to be collected typically include – onset duration progress of cardiac symptoms, similar complaints in the past, any other major illnesses like diabetes, hypertension, medicines with dosage, previous surgeries, any allergies, etc. Details are provided to the respective physician and orders noted accordingly. Meanwhile the patient and the relatives are provided counseling and assurance. Coronary Angioplasty is planned in this patient to widen the occluded coronary artery. These arteries supply blood and oxygen to the heart muscles. These arteries get occluded due to fatty tissue or atheroma resulting in reduced blood supply to the heart causing chest pain. Angioplasty is performed to open up the blocked vessels by compressing fatty tissue against anterior coronary vessel wall. This procedure helps to improve blood flow through the vessels to the heart muscles and helps in relieving chest pain. Also, this procedure is advised when - a. Medicines like calcium channel bloc ker, beta adnergic blockers or nitrates fail to correct coronary heart disease symptoms (NICE technology appraisal guidance 71) or b. There is recurrence of chest pain post CABG (Coronary Artery Bypass Graft surgery). Coronary angioplasty can be planned procedure or an emergency procedure in the case of heart attack and unstable chest pain with acute myocardial infarction. (Coronary Angioplasty and Stents) This operation is performed either through radial artery or femoral artery. Radial route is more popular in recent times because radial artery is easily accessible and palpable. Its superficial location makes it easy to compress to achieve homeostasis later on. Normal Allen’s test ensures dual blood supply to hand. So in case of bruise to radial artery or radial blood flow shunt, hands will still receive perfusion through Ulnar artery without feeling any damage. There is less chance of nerve injury in radial method. This approach provides comfort to the patient as it allows them ability to mobilize. It is easier for the patient to notice and control any bleeding from the radial incision, the femoral artery lies deeper in leg, so compressing the artery is difficult and by the time hematoma is noted bleeding would be significant. Radial artery method is cost effective too. (Radial Approach to Cardiac Catheterisation). Coronary Angiography is performed with the Angioplasty in an emergency. Angiogram allows doctor to look inside coronary arteries and find out how severe and where the narrowed areas are. (Coronary Angioplasty and Stents) Patient is advised what medicines to be avoided on the day of the procedure, such as aspirin or any anti coagulant, which medicines should be stopped few days before the procedure and what additional medicines need to be taken. He/she is also informed about the details of the procedure along with the effect of anesthetic drugs during and after the procedure. Doctor explains about the nature of pain the patient may have. Nu rsing staff ensures that patient would not eat or drink anything 4 -5 hours before the procedure. Proper consent is taken from the patient and relatives informing them about the complication involved in it. Nursing staff prepares the patient for the procedure by checking

BRAPS Coursework Example | Topics and Well Written Essays - 1750 words

BRAPS - Coursework Example Racal telecom was valued at one million seven hundred billion pounds. Racal telecom later detached itself from Racal Electronics in nineteen ninety one and formed what is today known as Vodafone group. Vodafone later bought two thirds of Talk land for around thirty million pounds in nineteen ninety-six. Consumers of Talkland, a one eighty one chain store, overpoweringly utilized Vodafone’s network. Correspondingly, Vodafone purchased a service provider entitled Astec Communications. Vodafone later unraveled its speech mark emblem in a circle and the â€Å"O† symbolizes conversation. Vodafone again agreed to amalgamate its assets in the United States with those of Atlantic Corp and designed Verizon Wireless. This amalgamation was finalized in the year two thousand. The corporate’s affiliates also operate under the label Vodafone. Vodafone Group plc.’s is headquartered in Newbury, United Kingdom. Vodafone being ranked as the most profitable telecommunications company in the world runs networks in over thirty nations and partners with forty other countries. Vodafone is managed by Gerard Kleisterlee who is the Chairman and Vittorio Colao who is the chief executive officer. Vittorio Colao joined the company in 2008. The company deals with telecommunications, which entails providing vocal sound and data services or amenities through mobile phones. The main products promoted by Vodafone include; Vodafone Freedom Packs and Vodafone Passport, Vodafone Mobile USB Modem and Amobee Media Systems, Vodafone at Home and above all Vodafone live. The company has also introduced money transfer services such as M-PESA. Vodafone’s Vision and mission is to lead the business in attending to the concerns of public members with regard to mobile telephones, staff, and wellbeing by representing principal practices and inspiring others to emulate, and, to be the communications forerunner in a technologically advancing world practices and inspiring others

A Letter to The Angel of Death Assignment Example | Topics and Well Written Essays - 500 words

A Letter to The Angel of Death - Assignment Example ever, although the above rational thinking gives me the courage to look at death in a constructive manner, I am an emotional human being who gets upset whenever you take away someone loved by me. Accordingly, I disclose below my encounters with death, which has always shaken me. He was in the hospital struggling to come out of the terminal illness that gave him lot of pain and anguish. Finally the end came. The doctor attending him asked each one of my family members to bid farewell to my grandpa. My dear angel of death, you were there ambushed in my thoughts, as I prayed to you for not snatching away my beloved grand father. However, he had to go and so he did. This emotional scene has lingered on to my memory, ever since. Many thinkers and philosophers have discussed the mystery involving process of soul leaving the body. However, this mystery could not be solved until today. I am satisfied to believe that God commands you, the Angel of Death, to take away our souls. At the same time, I wish to pray you for the following. I have witnessed people who believe that they are avoiding death by running away from you, as you keep on following them. However, I firmly believe that your appointment with them cannot be delayed even for a single second. It is all fixed, before you arrive. In the process, these people are fooling themselves by thinking they are hoodwinking you. The constant fear of death nearly kills them every moment. I have also witnessed people coming back to life after having a close encounter with death. However, I wonder if you are helping them to escape death at that precise moment. Knowing from the experience of many such people, I conclude that you did help them through such

Briefing Report on RKD Transport Case Study Essay Example for Free

Briefing Report on RKD Transport Case Study Essay This is a short briefing report based on research and critical analysis of various management literatures to develop solutions to the case study RKD Transport. As a graduate member of Business Consulting Group (BCG), I have been asked by the CEO to identify and evaluate issues that are perceived to be affecting work performance and cooperation at RKD Transport. The Managing Director (John) has asked BCG to review the situation as described in the case study, and has requested a report assessing the situation with comment on the issues that are raised and Johns proposed plan. This report also presents a range of options and recommendations as supported by research, which resolves the perceived problem about the implementation of John’s proposal a clear indication of the skills which can be taught to staff members. As of the dependable data in relation to what is taking place in the world of study into organizational behavior (OB) and management, the present line of thought and practice in OB programs can be applied to the case study. I. Point of View- graduate member of Business Consulting Group (BCG) Given the case material, the group has decided to take the point of view of the BCG’s graduate member on analysis to facilitate ease of recommending decisions to the management. II. Problem Statement The question posed by the case is thus: â€Å"What should the Managing Director, John do to effectively and efficiently introduce and implement his plan for the company? † III. Background of the Study Organizational behavior is concerned on personal and group dynamics in an institutional background and situation, over and above the character of the association themselves. Reports pertaining to this, try to figure out and form the various factors when persons in the group interrelate with one another. Comparable to all shared sciences, managerial studies seek to organize, forecast, and elucidate all the social happenings that are occurring in the given field, which can be taken as a foremost part in institutional progress and success. According to Arnold (2005), examples of the problems that OBM directs on are security, output, quality, and aptness. SWOT Analysis is the assessment by the decision making person or group of Strengths, Weaknesses, Opportunities and Threats regarding preferred final position or purpose of a task or business. The goal of every SWOT investigation is to recognize the chief inner aspects, the strengths and weaknesses to the institute and outer features, the opportunities and threats exhibited by the outside setting to accomplishing the intention. The case study should be defined as an investigation technique, using SWOT Analysis involved in a project or in a business venture, as stated by the MCRPC Regional Planning Commission (2005). Strengths are elements of the organization which are of use to reaching the goal of the management. The assets of the RKD Transport workplace are the following: monetary and intellectual terms, site, infrastructure, and fundamental training. However, the weaknesses which are detrimental to attaining the purpose of the management are the following: good organization, work appraisal of employees, developed methods for doling out with main fields of human resources, poor at pulling off consequences through undirected aid of individual vigor, and partial running skill and proficiency. The opportunities of the organization, on the other hand, are the following: desiring to progress on the whole managerial efficacy through directorial growth and social organization line up and more broad supervision prospects entailing improvement of new executives. And lastly, the threats are the following: human resource input are not acknowledged by the upper administration who dodge it by making use of external advisors and transference having the result of eliminating units and removing intermediate organization strata to develop flatter arrangement of institution. IV. Alternative courses of action Organization design is a conventional channeled means for assimilating the personnel, information and tools of an establishment. It is utilized to go with the structure of the corporation as thoroughly as feasible to the points the business pursues to accomplish. Through the design process, a corporation takes steps to expand the likelihood that the shared efforts of affiliates will be exultant. Additionally, the concept of job design is important here which indicates the manner that a series of everyday responsibilities and jobs, are structured. This makes easier to ascertain what, how, how many, and in what order the responsibilities are completed in connection with the organization. Its principles can also direct predicaments in the workplace such as labor under load, monotony, inadequate manipulation over occupation, deferral in filling unoccupied stations, and partial perception of the entire work course (Jones, 2004). Executives must use Organizational Behavior Management since the achievement of the business is credited with the efficiency of their courses of action and the pleasant response of the staff, incorporating the key functions of management such as â€Å"planning, organizing, leading and controlling† (Buchanan, 2004). Here is a variety of options and recommendations which may be implemented to solve the particular problem of the company. 1. Change the type of leadership from paternalistic to democratic for the voice of the employees to be heard. John, the Managing Director of RKD Transport, must change the way of administrating his subordinates. He must develop an employee-oriented method by trying to motivate his employees rather than direct or control his subordinates (Burns, 2003). Furthermore, he would have to depend not only to his own capabilities but must encourage his own subordinates to participate, thus, resulting to developing managerial abilities of the subordinates. The style of leadership of John, indeed, can have significant impact on the performance and satisfaction of his subordinates so his leadership style should have the characteristic manner in which he makes decisions affecting his subordinates and exercises influence to elicit their compliance with, commitment to, and support for his directives. He must encourage his subordinates in decisions that affect them, forming a friendly, trusting, and respectful leadership with group members, and must act promptly with this said concern. 2. Make a prior notice that the manager would downsize employees of the work force. It is indicated in the case problem that labor turnover is low. In order to achieve effective control over direct labor costs, John must apply downsizing and layoff strategies. But he must make use of consensus first in making decisions for the company for the employees to be given a chance to change their attitude towards work. These approaches for layoffs and downsizing will lessen the harm to those workers who will be laid off and to the employees who will stay behind. This also presents a practical prospect for a healthier outlook for the business and the business’ stakeholders. Downscaling in this way falls into the kind of administration means for accomplishing preferred adjustment, a good deal like downsizing examination. The following factors must be considered in considering this: Is the business being upright to its human elements? Has the necessary stipulation which may head to a number of complicated resolutions been conveyed to the business’s staff? Have the employees been able to supply input? Have the administration conscientiously supposed the outcome for those workforce? How will this influence those who may lose their work? How will this concern those who stay with their job? Does the strategy for modification present the business to attain improved outcome in the future? (Hickok, 2007). 3. The managing director would still be strict and objective, and would monitor the employees himself. John would continue to be hard-working, spending time inspecting the personnel and meticulously supervising the business process by plotting strategies, captivating counteractive deeds of this customary viewpoint. But some conflicts may arise because in implementing this kind of procedure. John’s status here as the person in charge is at risk in view of the fact that discords from his subordinates may take place against him (Haslam, 2003). 4. Assign more supervisors which will monitor the employees’ performance. By this course of action, the personnel can be monitored well if they are doing their jobs effectively and efficiently because they have to meet with the deadline. This could provide the management an objective assessment of each worker’s performance. It must be remembered that the input of workers in the business is a crucial part in the success of the company. 5. John must be further trained as managing director position in the company. To be considered an efficient and effective managing director, John must possess personality characteristics such as self confidence, aggressiveness, dominance, and adaptability. Additionally, he must also have the skills like sensitivity in dealing with others, intelligence, and job mastery which he can use in supervising his constituents. So he must be further trained to have these characteristics to become an efficient and effective leader. Successful directors essentially sets up a working atmosphere in which human resources would like to carry out their jobs properly. To realize the far more constructive work milieu, performance study edifies administrators on how to efficiently handle their positions as affirmed by Holman (2003). John may acquire the knowledge and skills though attending seminars, hands on training, and the like. 6. John must conduct research of the leadership style of former managers of the RKD Transport and examine what is the most appropriate approach in running the Management division. He must critically study the past records of the former managers of the company and their leadership styles and see what the best way of treating employees is during those times and apply it with the present situation, with the integration of interior appraisals of the business SWOT. This recommendation requires the enclosure of an evaluation of the current state of affairs, as well as the assessment of their extent. 7. RKD Transport pay rates must be adjusted to what the company can afford and are just right for the employees. Since workers perceive that the management was sympathetic to them, pay rates are considered high. Besides, there are other benefits offered to the employees by the company like sufficient compensation for shifting workers, provision for emergency loan, and many more. The conventional employee performance system relies on direct supervision, the wage and salary compensation system, and annual performance reviews, merit pay increases and promotions as rewards for exceptional performance (Staw, 2004); though an indispensable budgeting aspect must be of great consideration for the company’s success.

Divergent Suggested Essays Essay Example for Free

Divergent Suggested Essays Essay Suggested Essay Questions 1.In what ways does Triss identity develop over the course of the novel? Tris began the novel timid and unsure of herself and her desires, which was characteristic of her Abnegation upbringing: she was never allowed to focus on herself, so she never knew exactly what she wanted. Upon choosing Dauntless her bravery obviously begins to blossom, but she experiences some other changes as well. She forges friendships and relationships central to her identity, with people who bring out the best in her. And she learns that though she has chosen another faction, she can still be selfless; and indeed she is, time and time again. By the end of the novel, she is fully aware of herself as Divergent someone who does not fit in, but who cannot be controlled. The events of the end of the novel reinforce who she has been selfless and who she wants to become brave. There are many significant experiences to discuss, both good and bad, that shaped Tris as a person throughout her time in Dauntless. 2.Compare and contrast this rigidly structured society with our own. What are the pros and cons of each? Does one provide a more effective lifestyle than the other? The distinctions between Triss society and our own are very apparent; their idea of becoming a good person involves selecting one virtue to cultivate their entire lives, while for us, being good and morally sound involves a mixture of all of their faction virtues and more. Socially, we have much more freedom of choice, but is that freedom always a good thing? Studying any of the five virtues of Triss world can indeed have positive effects on ones life. It all depends on perspective; either could be seen as the more effective lifestyle, depending on how you look at it, but the faction system certainly makes some significant missteps in trying to control and direct a persons identity and humanity. 3.Discuss the soundness of a government run only by a single faction. Is Jeanine Matthews truly wrong for calling for greater representation, or is it better to keep administration in the hands of the selfless? This is certainly a far cry from our system of democracy. While having the innately selfless run the government seems like a respectable idea in theory, in practice it may fall short. Abnegation do not have the same goals in life as Erudite, Candor, Amity, or Dauntless, so therefore it is natural that their administration is called into question. Perhaps a system with equal representation from every faction would be a better strategy; though policy would not consist of extremely selfless acts, sometimes representatives do have to be selfish advocates for their people. And with everyone having a say, there would be much less chance of a rebellion the size of Erudites. Jeanine wasnt entirely wrong in what she preached, but she certainly went about it the wrong way, and Abnegation wasnt to blame for a system that had been flawed from the start. 4.What are the benefits of sorting people into social groups the way the factions are sorted? What are the drawbacks? We tend to subconsciously sort ourselves into groups regardless; we gravitate towards people with similar interests as us, people with similar backgrounds, people who look like us. With a society organized into groups, citizens are always surrounded by like-minded people, and there is a much greater chance of getting along with those who think like you. On the other hand, though, that separation can promote intolerance and prejudice, which is obviously apparent in the novel; all the factions shunned the values of their competitors, promoting a far too separated way of life. 5.There are only five factions; are there any other human virtues missing from the list? Why would these be necessary in well-rounded citizens? Valuing only honesty, selflessness, peacefulness, bravery, and intelligence seems like a very small slice of the vast majority of honorable human virtues. Another faction could exist based on loyalty; many of the problems  in Triss world (and our own) are caused by betrayal and distrust. A faction based on diligence could ensure that all its citizens are hardworking and productive. And there could also be a faction based on creativity, which shapes the mind in many ways the other factions do not. 6.Discuss Tris Prior as our protagonist. Is she a reliable narrator? Does she always tell the truth? Are we constrained by her point of view? Tris is typically a very straightforward narrator, though perhaps her point of view is often clouded by her own personal prejudices. We do not get a good sense of Peters character, for instance, because she is always so determined to hate him; perhaps there is more to him than meets the eye. Were certainly constrained by her perspective, only knowing what she knows at any given time. We solve the mysteries of Four, her mother, and the Erudite-Abnegation feud only as soon as she does, because the story is told only from her first person perspective. The limits of this perspective does allow for some mystery and tension, though, as well as the strong impression of Tris as a hero. 7.What significance do Triss relationships have in her life? Various relationships begin to blossom for Tris only after shes left Abnegation. Her family is broken apart, but at a distance she seems to get even closer to her mother, learning more about her past than she ever knew before. In Abnegation, Tris never had true friendships, but in Dauntless she becomes close to Will, Christina, Al, Uriah, and some of the other initiates. Without them, she wouldnt have had the support she needed to get through initiation. And finally, her relationship with Four has changed her in many ways; shes been given someone to open up to, who in turn opens up to her, and for a person with as much to deal with as Tris, this is absolutely essential. 8.Compare and contrast Peter and Jeanine Matthews as antagonists. Who would be considered the central antagonist? Both Peter and Jeanine serve as Triss enemies, but in very different ways. Peter is more present throughout the novel, causing trouble for Tris during initiation, her most immediate concern. But Jeanine is an antagonist on a larger scale; though she doesnt make an actual appearance until late in the novel, we know shes been behind the growing rebellion of the Erudite and the hunt for Divergent. Jeanines aims and the reach of her grasp lead to something much, much larger than a struggle for ranking during initiation. For this reason, only Jeanine can be considered the central antagonist. 9.In what ways is the brewing war between Abnegation and Erudite reminiscent of our societal power struggles? Though the battle at the culmination of the novel is fought with high-tech innovations like simulations, the circumstances that caused it can be easily compared to the power struggles in our own society. It starts with a group of people believing theyve been treated unjustly, with an unfairly small amount of say in government, and ends with a bloody battle to determine who stays and who goes. Revolutions and major modern-day wars begin in much the same way. Jeanine Matthews is representative of the persuasive, charismatic, and intelligent leader who is able to convince her people to rally against another group; in this case, Abnegation. Jeanines method of manipulation through propaganda (false claims about Abnegation) and disrespect for others based on a perceived difference or lack mirrors fascist leaders from history. 10.Which theme in the novel would you consider the most significant, and why? Though many major themes in Divergent are prevalent, the one that constantly comes into play is the theme of identity and how ones choices determine self. Tris is constantly making choices that define who she is, starting with the major one on Choosing Day and continuing throughout initiation, ending with her decision not to shoot Tobias in the control room in order to stop the simulation. Her identity develops further with every decision, and eventually she learns that she can truly be brave and selfless at the same time. This theme applies to other characters as well; Caleb, for instance, chose to switch to Erudite in order to stay true to his own identity, but  eventually returns to Abnegation because he decides that Erudites plans were wrong, and he could not be a part of it. Each and every character in the novel makes at least one choice that aids in determining their identity; therefore, this theme is extremely significant.

Role of Metformin for Treatment of Type Ii Diabetes Mellitus

Role of Metformin for Treatment of Type Ii Diabetes Mellitus The role of metformin in the treatment of type II Diabetes Mellitus Introduction: Diabetes mellitus is a sever inherited or acquired disease which occurs when either pancreas does not produce enough insulin, which characterises type I diabetes and it is most commonly diagnosed in children, or the insulin that has been produced does not get used by the body effectively, type II diabetes and therefore patients will have abnormally high level of glucose. Type II diabetes was previously called non-insulin-dependent or adult-onset diabetes (World Health Organisation, WHO website). The latest estimate of the number of diabetics worldwide in 2001 by the World health Organisation (WHO) is 171 million and this figure is likely to be doubled by 2030 (WHO website). A recent study conducted in the UK using the General Practice Research Database (GPRD) illustrate that the mortality rate is twice as high for patients with diabetes type II than those without it (Mulnier et al, 2006). The prevalence of type II diabetes is increasing rapidly both in the UK and worldwide. It has increased by 54% (from 2.8% to 4.3%) and the incidence has increased by 63% over the past decade (Gonzalez, 2009). In most of the cases Type II diabetes is associated with another disorder, obesity, (Krentz et al, 2008). Hence such high increase in the incidence rate for type II diabetes could be due to the increased rate of obesity over past few years as the life style of the population is generally getting poorer and 20% of the population is now obese (UK Obesity Statistics). Understanding and treatment of diabetes has advanced throughout the twentieth century and since insulin has been discovered, many antidiabetic therapies and oral agents such as, Sulphonylureas and Biguanides have been developed to improve glycaemia. Sulphonylurea was the first oral therapy to be discovered for diabetes. It is insulin secretagogues and hence it combats the abnormally high level of blood glucose but it also causes hypoglycaemia and weight gain as it can prolong insulin secretion (Warrell et al, 2006). Biguanides is a class of drugs that are considered antihyperglycemic agents. Metformin is a primary member of this class and it has surpassed sulfonylureas as the most prescribed oral antidiabetic drug in the UK and most parts of the world (Filion, 2009). Metformin is now the most popular treatment for diabetes type II as a study carried out using The Health Improvement database from 1966 to 2005 in the UK shows that only a small number of patients were treated with insul in and its use did not change significantly over the time of study period, in 1966 Sulphonylurea was the most common drug and metformin was relatively less common but by 2005 the use of Sulphonylurea had decreased remarkably and there had been a parallel increase in the use of metformin as a therapy for diabetes (Gonzalez, 2009). In 2006 the American Diabetes Association recommended it as the first drug of choice for patients. In the 15th edition of the Model list of Essential Medicine by WHO, metformin is one of the only two antidebetic oral drug agents (the other is glibenclamide) stated there (WHO, 2007). The other members of biguanides drug class are phenformin and buformin however these two drugs are no longer used in many countries because it carries a very high risk of lactic acidosis. Historical development: In medieval times, French lilac or Goats rue known as Galega officinalis was used as a remedy for intense urination associated with the disease that is now known as diabetes mellitus and the active ingredient in the French lilac that had blood glucose lowering properties was discovered as galegine or isomyleneguanidine, but later on it was discovered that this ingredient was toxic in the plant that caused death of grazing animals (Witters, 2001). In 1918, guanidine was discovered to be blood glucose lowering agent but then it was also found that it is too toxic to be used as a therapy (Foye, 2007). Whilst guanidine itself and some of its other derivatives were considered to be too toxic to be used for diabetes mellitus treatment, the biguanides, two linked guanidine, proved to be safe and effective for the treatment of diabetes (Witters, 2001). In the 1920s, in a search for these guanidine-containing compounds with antidiabetic activities, phenformin, buformin and metformin were discovered. Although they were known to have glucose lowering properties it was not until 1957 when these biguanides were tried on man and introduced clinically in Europe (Gottlieb Auld, 1962, Reitman Schadt, 2007). For the first time in a medical literature by Ungar et al (1957, as cited by Oubre et al 1997) biguanides were described as an efficacious new class of oral drug for the treatment of diabetes. Phenformin which is similar to metformin in structure was very popular in 1960s but in early 1970s it was found to be associated with lactic acidosis and by 1976 clinical studies proved that the hazards of phenformin treatment outweighed its benefits and therefore, phenformin and all the products containing phenformin were withdrawn by the Ministry of Health and buformin was also withdrawn from many countries for the same reason (WHO, 2003). Howe ver, metformin was proved to be safer and did not have same risk of lactic acidosis if appropriately prescribed, and it took another twenty years after a safe and effective use in the Europe until United States Food and Drug Administration (FDA) approved it for use in the United States (Reitman Schadt, 2007). Glucophage the trade name of metformin, formulated by a drug company called Bristol-Myers Squibb, was the first brand to be marketed in the United States (U.S. FDA). Metformin used to be only prescribed for diabetes but then studies published in European journal of clinical investigation 1998 proved that metformin can have a significant effect on reducing weight as well (Paolisso et al, 1998). Meformin has now been used for over 50 years and it has established to be first-line drug of choice for the treatment of diabetes type II, but to get its maximum effect in the anticipation to reduce insulin resistance, weight loss and also to contribute in the improvement of cardiovascular diseases,the American Diabetes Association and the European Association for the Study of Diabetes strongly recommend to use metformin along with lifestyle intervention (Papanas Maltezos, 2009). Mode of Action/ Physiological Effects: Metformin is an antidiabetic oral drug that belongs to a class of drugs called biguanides. It acts by lowering the amount of glucose that liver makes on its own in the body hence it has antihyperglycaemic effects. It was licensed as antihyperglycaemic medication in Europe in 1970s, at that time there was only little known about the mode of action and its physiological effects on body. Despite metformin being in use since 1950s, its cellular mechanism of action is not definite. It primarily acts by inhibiting gluconeogenesis in the liver and hence it reduces the hepatic glucose output; it has also been shown to enhance glucose uptake in the muscles and improve peripheral insulin sensitivity (Ronco et al, 2008). Insulin is a very powerful anabolic hormone and it is involved in the synthesis and storage of glucose, lipid, and amino acid/protein. When blood glucose level rises, insulin is produced by the beta cells of the pancreas. As described by Gropper et al (2008) in their book, it stimulates the uptake of glucose by muscle cells and adipocytes, it also inhibits the gluconeogenesis by the liver to bring about an overall decrease in plasma glucose level. Insulin binds to a specific receptor on the plasma membrane of muscle cells and adipocytes which initiates a cascade of second messenger system that stimulates the tubulovesicle-enclosed GLUT4 glucose transporters to be translocated to the plasma membrane. Insulin also activates the enzyme glycogen synthase and inhibits glycogen phosphorylase and together they help store glucose in the form of glycogen. Hence this way glucose is removed from the blood circulation and is brought to normal level (Gropper et al, 2008). The majority of individuals with type II diabetes are insulin resistant. They have plenty of insulin circulating but their body is not able to respond to it either by having defective or insufficient number of insulin receptors therefore, glucose cannot enter the cells resulting in increased level of plasma glucose. Pancreas continues to produce more insulin in an effort to lower the increased level of glucose and eventually when an individual can no longer produce enough insulin to compensate for the rise, type 2 diabetes develops (Kaufman, 2008). Figure 1shows an overview of antihyoerglycaemic effect of metformin in type II diabetes mellitus. Metformin has various metabolic effects on lowering the hyperglycaemia. It partially acts by improving insulin action and partially by non-directly insulin dependent effects (Krentz Bailey, 2005). Metformin suppresses the hepatic glucose output by decreasing gluconeogenesis, glycogenolysis and fatty acid oxidation and this is the most evident principal blood glucose lowering mechanism and it does so by mainly increasing insulin sensitivity (Krentz Bailey, 2005). In the skeletal muscles metformin increases the insulin mediated glucose uptake and glycogen formation (glycogenesis), it also reduces the fatty acid oxidation. These changes in the muscle cells increase glucose transporters to move to the plasma membrane surface so that glucose can enter the cells (Krentz Bailey, 2005). Another way in which metformin lowers hyperglycaemia is via increasing the anaerobic metabolism of glucose which produces lactate as a by-product and this contributes in lowering the amount of glucose available to move to the serosal side from the lumen, lactate is taken to the liver via portal system (Bailey et al, 2008). Another way in which metformin works independent of insulin action to lower glucose is via increasing the splancchic glucose turn over (Krentz Bailey, 2005). The effect of metformin on skeletal muscles and adipose tissues in improving glucose utilisation in them appears to work through improved binding of insulin to its receptors on the plasma membranes of these cells and therefore, metformin seems to be ineffective without some residual functioning islet cells (Porte et al, 2002). Metformin has no direct effect on insulin secretion in contrast to other antidiabetic drugs such as sulfonylureas, therefore it does not cause hypoglycaemia rather in clinical practice it shows anti-hyperglycaemic actions (Porte et al, 2002). The level of glucose throughout the day changes, it is typically higher after eating and lower in the fasting state. The fasting plasma glucose concentration is measured by the HbA1c test, HbA1c is a glycosylates haemologlibin that is glucose attached with hamemoglobin so the higher the concentration of glucose the higher the level of HbA1c ( Medline Encyclopaedia, 2009). A fasting glucose level lower than 6mmol/l or 7% is normal in non-pregnant individuals and an elevated level shows that either the patient is diabetic or the patient has impaired fasting glucose/impaired glucose tolerance (Bupas health information factsheet, 2008; American diabetes association, 2009). It is important for type II diabetes patients to achieve normal or near-normal glycaemic control with their oral anti hyperglycaemic medications. There are numerous studies that show the effect of metformin decreasing the fasting plasma glucose level. Such as a study by Lozzo (2003), done on type II diabetes patients over 26 weeks with metformin increased the whole-body insulin sensitivity and that was likely to be determined by the reduction in HbA1c and body weight. A similar study done on patients with newly diagnosed Type II diabetes mellitus showed that adding metformin to insulin therapy effectively decreased the HbA1c level from 10.8 to 5.9% and 100% patients achieved an HbA1c less than 7% (Lingvay, 2007). Metformin has also been suggested to work by a biochemical pathway through activation of a protein kinase enzyme 5 adenosine monophosphate-activated protein kinase (AMPK). Its activity is regulated by the depletion in ATP (Adenosin tri-phosphate) and raised level of AMP when energy demand increases, such as in a exercising muscle, thus it is a â€Å"metabolic stress-sensing enzyme† that regulates the energy demand and energy production balance by modulating various metabolic pathways that bring about glucose, protein and fatty acid metabolism homeostasis (Hawley Zierath, 2008). In order for metformin to be effective in the inhibition of the production of glucose, activation of AMPK is required (Zhou, 2001). Kim et al (2008) published a study in 2008 that further described the mechanism of metformin through the activation of AMPK. This study was done on hepatocytes and it showed that through AMPK-dependant pathway metformin increased the gene expression of small heterodimer pa rtner, (SHP), SHP protein represses the transcriptional activity of a number of nuclear reptors including hepatocyte nuclear factor, and that in turn inhibits the expression of the hepatic gluconeogenic genes PEPCK and Glc-6-pase, these are the two enzymes that perform a key role in the homeostatic regulation of blood glucose levels and inhibition of these enzyme gene expression lead to the hepatic glucose production in vivo. Metformin has advantageous effects on atherosclerosis by decreasing Low Density Lipoprotein levels by about 0.26 mmol/L (10 mg/dL), whereas other oral agents appear to have no obvious effects on LDL cholesterol levels (Bolen et al, 2007). Recent prospective and retrospective studies confirm this drug not only being safe for its glucose lowering effects but also indicate its potential anti-atherosclerotic and cardioprotective effects (Scarpello Howlett, 2008). In the UKPD (United Kingdom Prospective Diabetes Study) a randomised trial on obese and overweight patients with initial metformin monotherapy showed a significant reduction in myocardial infarction and diabetes related deaths, it showed 39% decrease in heart attacks and 36% decrease overall mortality rate; metformin was found to be more effective than any other medication with regards to the strokes and overall mortality rate in overweight patients (Krentz Bailey 2005). Kooy et al (2009) investigated whether metformin had sus tained beneficial effects on metabolic control and risk of cardiovascular disease. After a follow-up period of 4.3 years it was found that metformin added to insulin in type II diabetic patients improved body weight, glycaemic control and it reduced the risk of macravascular disease. A 2007 systematic review evaluating antidiabetic agents and outcomes in patients with both diabetes and heart failure showed that metformin is the only antidiabetic agent that is not associated with harm in patients with heart failure and diabetes. In this systematic review and meta-analysis of controlled studies, two of three studies showed association of metformin with reduced all cause mortality and no association with increased hospital admissions. (Eurich et al, 2007) Pharmacokinetics The chemical name of biguanide is  1-(Diaminomethylidene)guanidine (chemical  formula C2H7N5) and it includes compounds that  have biguanide structure. Figure 2 shows the  molecular structure of metformin that has  biguanide structure with two methyl groups  added on the amine group of the first carbon  atom therefore its chemical name being  1,1-dimethylbiguanide and chemical formula  C4H11N5 (Porte et al, 2002). Metformin is taken orally so it has to pass through the digestive system in order to get into the systemic circulation. It is absorbed from the small intestine and does not get metabolised, under fasting conditions the Bioavailability of metformin ranges between 40%-60% (Foye, 2007). From the gastrointestine it gets completely absorbed after 6 hours of oral administration and after absorption it is rapidly distributed and in the plasma it is completely undetectable after 24 hours; the plasma concentration of metformin reaches its peak value within three hours of its oral administration (Papanas maltedoz, 2009). Unlike other biguanides such as phenformin the binding of metformin to plasma protein is negligible and therefore it does not seem to interact with highly plasma protein bound drugs such as sulphonamides and is excreted unchanged (Foye, 2007). Metformin does not get metabolised by the liver and therefore is excreted in the urine from the body as unmetabolised drug through the active tubular excretion and about 30% of an oral dose is excreted through faeces that may be unabsorbed metformin and that retain in the gastrointestinal tract (Porte et al, 2002). It has plasma half life of about 2 to 5 hours in patients with normal renal function but and renal function impairments may lead to retention of metformin in the blood plasma (Foye, 2007). According to Diabetes UK the daily dosage of metformin should be started from 500mg and then gradually increased to a maximum of 2550mg per day but it is entirely individualistic that it depends on the health of individual to consider what dosage is required. Generic metformin is sold in the form of tablets. A slow or extended release preparation of metformin (Glucophage XR ®), introduced in 2004 can act over 24 hours, it has been designed to release metformin slowly over a longer period of time than standard metformin (acts over 8-12 hours) and so its half life is increased to four to eight hours. Timmins et al (2005), in their study on 16 volunteers with 1000mg standard metformin dose twice a day or 2000mg Glucophage XR ® once a day, found out that the pharmacokinetics parameters are similar in Glucophage XR ® to standard metformin, but Glucophage XR ® it is evident to report fewer gastrointestinal side effects than standard metformin so patients who cannot tolerate standard metformin can switch to Glucophage XR ® (Feher et al, 2007). Side effects and contradictions When prescribed appropriately the most common adverse side effects of metformin include a change in taste, nausea or vomiting, abdominal distension or gas, loss of appetite, diarrhea, skin rashes or urticaria, rare – Lactic acidosis (Warrell et al, 2006). These problems are usually mild and occur in the first few weeks for taking the medication but it may discourage the patient from taking the drug, starting the medication in low dosage and increasing it slowly help reduce these side effects (Warrell et al, 2006). In clinical trial done on a total of 286 subjects, 141 were given metformin and the rest were put on placebo. This trial found that 53.2% of subjects who were given Metformin reported diarrhea in comparison with 11.7% for those on placebo, and 25.5% subjects on metformin reported nausea/vomiting compared with 8.3% for those on placebo (Drug Facts and Comparisons, 2005). Compared with any other antidiabetic oral drug metformin is most associated with gastrointestinal distress (Bolen et al, 2007). Phenformin was withdrawn from its theraputical use because of its association with lactic acidosis. Metformin which is similar in structure to phenformin has also been associated with lactic acidosis; however the risk associated with metformin is ten times lower than phenformin (Warrell et al, 2006). A case control analysis on the study population of 50,048 type 2 diabetic subjects using the U.K – based General Practice Research Database found out that the rate of incidence of lactic acidosis per 100,000 person-years is 3.3 cases amongst metformin users (Bodmer et al. 2008). Lactic acid is a by-product of metabolism and it becomes toxic if it is not neutralised fast enough. Lactic acidosis associated with metformin is a very severe and potentially fatal condition that can be avoided easily if the drug is prescribed carefully (Fitzgerald et al, 2009). It arises by the mode of action of metformin, that is the inhibition of hepatic gluconeogensis- a process that consumes lactate, produced by glycolysis, continuously to produce glucose (Warrell et al, 2006). Adopted from Fitzgerald et al. BMJ 2009 In normal conditions during respiration glucose is broken down into two pyruvate molecules in the first step (glycolysis), in the presence of enough oxygen mitochondria oxidises the pyruvate into CO2 and H2O through Kreb cycle by the use of pyruvate dehydrogenase enzyme. But if there is not enough oxygen present, the mitochondria cannot oxidise all of pyruvate so this excess amount of pyruvate is converted into lactate by the lactate dehydrogenase and this lactate is then used in the process of gluconeogenses in the liver. (Fitzgerald et al, 2009; Nicks A, 2009) As shown in figure 3, at site A metformin decreases the activity of pyruvate dehydrogenase and the conversion of pyruvate into CO2 and H2O, therefore at site B it enhancing the anaerobic metabolism even in the presence of enough oxygen and resulting in the increased production of lactate and as metformin inhibits the process of gluconeogenses in the liver, the lactate is not used up and is built up to the toxic extent. Lactic acidosis is the built up of lactate level in the blood (usually >5 mMol/L). (Nicks A, 2009; Fitzgerald et al, 2009) As indicated in figure 3, lactate is excreted 70% by liver, 5% by kidneys therefore liver or renal dysfunctions lead to the retention of lactate and hence to a severe form of lactic acidoses even in the absence of metformin and because metformin is excreted by kidneys if kidneys do not function properly then metformin builds up and hence the severity of lactic acidosis is even greater (Misbin, 2004). The most common contraindications to the use of metformin in people with type II diabetes are renal and liver dysfunctions, congestive heart failure and advanced age, ≠¥ 80 years, and the mortality rate of lactic acidosis is close to 50% (McCormack et al, 2005). But although heart failure has long been known as a contraindication for metformin use a systemic review 2007 showed that metformin is the only anti-diabetic drug that is not associated with any harm in patients withheart failure Eurich et al, 2007). A Medline searched review on the evidence for the use of metformin in the presence of these contradictions concludes that metformin treatment alone does not result in lactic acidosis unless other contributing factors exist as well (Tahrani et al, 2007). However if ingested in toxic doses or in the presence of renal elimination impairment, lactic acidosis does occur (Fitzgerald et al, 2009). The renal function of patients using metfomin should be regularly monitored. It showed be withdrawn if there is any disturbance in the renal function found. Figure 4 shows the current recommendations on contraindications and guidelines for the withdrawal of metformin. Metformin dose should be reviewed if serum creatinine level is greater than 130  µmol/l and a cut-off serum creatinine level above which metformin should be stopped is 150 µmol/l (Fitzgerald et al, 2009). It should be withdrawn during suspected tissue hypoxia that is a condition in which body tissues are deprived of adequate oxygen so cells are forced to respire anaerobically. Patients aged greater than 80 years are at greater risk because they are more likely to have heart problems and kidney or hepatic dysfunctions and patients should be more careful about their alcohol intake while they are on metformin because alcohol can seriously harm liver and that can lead to lactic acidosis (Tahrani et al. BMJ 2007). Metfor min should be withdrawn before any radiographical procedures involving iodinated contrast and should remain discontinued until after three days as this contrast dye may temporarily impair kidney function and cause the retention of metformin indirectly leading to lactic acidosis (Thomsen andMorcos, 2003) â€Å"Review dose of metformin * If serum creatinine is >130  µmol/l or estimated glomerular filtration rate is Stop metformin * If serum creatinine is >150  µmol/l or estimated glomerular filtration rate is Withdraw metformin* * During periods of suspected tissue hypoxia (such as myocardial infarction, sepsis) * For three days after use of contrast medium that contains iodine * Two days before general anaesthesia *Reinstate when renal function stabilises Contraindications * Renal dysfunction * Congestive cardiac failure needing drug treatment * Hypersensitivity to metformin * Acute or chronic metabolic acidosis * Impaired hepatic function Precautions * Age >80 years until renal dysfunction ruled out * Acute myocardial infarction * Radiological studies involving iodinated contrast * Surgical procedures * Alcohol intake † Salpeter et al (2003), in a system review considered 194 studies published between 1, 1959, and March 31, 2002 that evaluated metformin mono therapy or in combination with other treatments for at least one month, in data from these 194 studies there were no fatal or nonfatal lactic acidosis cases found in 36,893 patient-years in the metformin group or in 30,109 patients-years in the nonmetformin or placebo group. It also did not find any difference in lactate levels in metformin therapy and placebo or other non-biguanide therapies. This systemic review concluded that there is no evidence to support association of metformin therapy with increased risk of lactic acidosis or increased lactate level compared with other antihyperglycemic treatments provided that the drugs are prescribed in a suitable dose and all the contraindications are taken into account. Another side effect to the use of metformin is that when it is used in long term it is associated with malabsorption of vitamin B12 (Ting et al, 2006). Combination with other antidiabetic drugs Metformin monotherapy works well with life style interventions in type II diabetic patients but when Type II Diabetes is not controlled with Metformin monotherapy adequately it is often combined with other antidiabetic drugs to maximise its effect. The combination of metformin with rosiglitazone as a single product is known as Avandame, itwas approved by the FDA in October 2002 for the treatment of diabetes and although it has not been appraised by the National Institute for Clinical Excellence (NICE) yet it is often prescribed to patients with type II diabetes who fail to control their glycaemia despite the maximum dose of metformin (Diabetes UK, 2009). The active constituent of Avandamet, metformin and rosiglitazone,have different mechanism of action complementing the action of each other. The tolerability profile of Avandamet is similar to that of metformin, it is more effective in terms of lowering the HbA1c level than metformin or rosiglitazone (Wellington, 2005). Pooled data from two double-blind studies that involved 550 patients randomised to be given metformin with rosiglitazone or placebo patients were divided into obese, overweight or non-overweight. Patients from all groups improved their level of HbA1c and fasting plasma glucose (FPG) to a clinically important extent but the greatest improvement was found in the obese group, these patients improved their glycaemic control, beta cell function and insulin sensitivity with the addition of rosiglitazone to metformin than those who received placebo/metformin (Jones et al, 2003). Metformin can be combined with glyburide which is a member of sulphonylureas and it acts by enhancing insulin release from the cell of pancrease. The combination of these two drugs is proves to be successful in improving the glycaemic control in patients with type II diabetes Studies, such as sixteen week multicenter, randomized, double-blind, 4-arm and parallel clinical trial study (Chien et al, 2007) that involved a total of 100 Chinese patients with type II diabetes and out of which 76 were randomly given metformin 500mg, glyburide 5mg, glyburide/metformin 2.5 mg/500 mg or glyburide/metformin 5.0mg/500mg. After 16 weeks, those who received a combination of both drugs had a greater decrease in both fasting plasma glucose and HbA1c compared with those who received either metformin or glyburide. Insulin therapy alone sometimes fails in patients for the treatment of type II diabetes so metformin can be added to improve the sensitivity of insulin and this combination of two drugs results in superior glycaemic control compared with metformin or insulin alone and it also minimizes the weight gain in insulin therapy ( Wulffele et al, 2002). Continued use of metformin after insulin introduction patients with type II diabetes not only reduce weight and improve glycaemic control but have beneficial effect on cardiovascular outcomes (Kooy, 2009). Addition of pioglitazone to metformin is another combination for the treatment of type II diabetes, this is shown in double-blind, placebo-controlled, clinical trial done by Kaku (2009), compared with metformin monotherapy patients who received pioglitazone plus metformin improved their HbA1C by mean 0.67% and they significantly improved their fasting glucose level and other important markers such as free fatty acids, adiponectin and HDL, that are linked with increased insulin resistance and cardiovascular risks. Metformin can also be combined with other antidiabetic oral agents as a triple therapy for diabetes type II. In a study which was supported by Bristol-Myers Squibb Pharmaceutical Research Institute, 365 patients who were given metformin/glyburide treatment prior to a 24-week double-blind treatment were either assigned to rosiglitazone or placebo while carrying on with metformin, 40% of those patients who received rosiglitazone in addition to metformin/glyburide were able to achieve final HbA1c less than 7.0% and this study concluded that combination of rosiglitazone to metformin/glyburide is â€Å"an effective therapeutic strategy† for those who are unable to control their glycaemia and this treatment is beneficial for lowering HbA1C and fasting plasma glucose levels (Dailey et al, 2004). Who should be treated? Metformin is a very effective antihyperglaecamic drug for patients with diabetes type II and the American Diabetes Association (2006) recommended it as the first drug of choice for patients. Metformin is a preferred treatment for obese diabetics. In most of the cases Type II diabetes is associated with another disorder, obesity (Krentz et al, 2008). Obesity increases the risk of developing type II diabetes and many antidiabetic drugs increase body weight whereas, metformin demonstrates a significant weight loss in type II diabetic patients, Golay (2007) in his review on summarising the effect of metformin on body weight confirms that metformin has been shown to induce weight loss in nondiabetic obese patients, although long term studies on these patients are very rare. Therefore patients with obesity and on the risk of developing diabetes type II should start on metformin. Metformin is also effective with regards to strokes in obese/overweight patients i.e. those on the risk of developing diabetes. UKPD showed a significant reduction in myocardial

Essay examples --

Scientists have been successful in the areas of cloning before, but a breakthrough in 2013 is helping the area of stem cell usage. There is much controversy over the use of stem cells, but this new technology may help lessen that. Using a technique called â€Å"somatic cell nuclear transfer,† researchers cloned a human embryo. Within an embryo are embryonic stem cells, which are unique because of their never-ending list of uses. Stem cells are a crucial part of many new medical research projects because they can be manipulated into producing any type of bodily cell, including more stem cells. With the use of stem cells, scientists may be able to produce organs, create vaccines, and possibly find cures for many diseases. Cloning has been a goal of scientists and researchers for decades. In 1996, the first mammal was successfully cloned: a sheep named Dolly. Then, in 2007, researchers at the Oregon National Primate Research Center cloned the embryos of primates. The goal of embryonic cloning is to extract embryonic stem cells, which are desirable because of their wide variety of uses in research. Embryonic stem cells are rare because they are found only in a four or five day-old embryo. In 2013, researchers achieved an astonishing breakthrough by cloning a human embryo and thus, were able to extract embryonic stem cells. This breakthrough is crucial to the development of stem cell research, since it is a way for stem cells to be used without harming a living human embryo. While there are other alternatives to retrieve stem cells, including the reprogramming of an adult stem cell to create an induced pluripotent stem cell, such technologies have not yet been perfected. In May of 2013, an 8-month-old baby with a genetic disease was brou... ...oping stages, there are no major vendors or customers. In the future, once laboratories perfect treatments using stem cells, they will be the vendors to the hospitals hoping to use those technologies to treat patients and save lives. I believe the use of stem cells will have a positive impact on our society. We are always looking for ways to cure any diseases that affect our everyday lives, from cancer to diabetes. With the use of stem cells, we could see a cure for these diseases in the future and millions will benefit. The cloning of embryos to extract embryonic stem cells is an amazing breakthrough for scientists worldwide. The possibilities for stem cell use are endless and cloning is a new way to achieve them. Potential problems may include further ethics debates and a possible shortage of donor eggs, but I believe scientists will overcome these obstacles.

Discrimination Against the Deaf Culture Essay -- Discrimination Again

The deaf community does not see their hearing impairment as a disability but as a culture which includes a history of discrimination, racial prejudice, and segregation. According to an online transcript,â€Å"Through Deaf Eyes† (Weta and Florentine films/Hott productions Inc., 2007) there are thirty-five million Americans that are hard of hearing. Out of the thirty-five million an estimated 300,000 people are completely deaf. There are ninety percent of deaf people who have hearing parents (Halpern, C., 1996). Also, most deaf parents have hearing children. With this being the exemplification, deaf people communicate on a more intimate and significant level with hearing people all their lives. â€Å"Deaf people can be found in every ethnic group, every region, and every economic class† (Weta and Florentine films/Hott productions Inc., 2007). The deaf culture and hard of hearing have plenty of arguments and divisions with living in a hearing world without sound however, that absence will be a starting point of an identity within their culture as well as the hearing culture (Weta and Florentine films/Hott productions Inc., 2007). In today's times, it is possible for a deaf family to characterize themselves as an all American family. For many centuries hearing people classified deafness as a horrendous misfortune. As reported by a historian at the University of Iowa, Doug Baynton, in the early 1800's most of the deaf people in America lived in segregated rural areas from one another, and with little communication with the people around them. â€Å"They also had a limited understanding of what they could do – of their own possibilities. People with deaf children really had no idea of what their children could achieve† (Baynton, D., 2007). There... ...eline of hearing devices and early Deaf education [Fact sheet]. Washington University School of Medicine, St. Louis, MO: Author Gallaudet University. (1997). Public relations Gallaudet University: The beginnings. Gallaudet University, 1-17. Retrieved from http://pr.gallaudet.edu/ Halpern, C. (1996). Halpern: Listening in on deaf culture. University of Colorado Journals, 1-6. (Original work published 1995). Retrieved from http://www.colorado.edu/ National Institute of Health. (2011). National Institute on Deafness and other communication disorders: Improving the lives of people who have communication disorders. National Institute on Deafness and other communication disorders,2-2. Retrieved from http://www.nidcd.nih.gov/ (Weta and Florentine films/Hott productions Inc. (2007). Film transcript: Through Deaf Eyes. PBS, 1- 69. Retrieved from http://www.pbs.org/

Accounting Essay -- GCSE Business Marketing Coursework

Accounting Accounting is a career that offers many job opportunities and advancements, and a little hard work will inevitably lead to happiness and success. Accountants have different duties depending on the size and nature of the company where they are employed. Usually accountants prepare and analyze financial reports that polish up-to-date information for government agencies, businesses, and other organizations. The data accountants provide information that influences nearly every business and government decision. This is important because a company’s financial condition is the most important thing. Accountants also have many opportunities for part-time work especially with small businesses. There are four major Accounting fields: Management, public, government, and internal auditing. Most accountants are management accountants that are usually employed by a single company to handle their financial records. A few management accountants function as internal auditors, a fast growing field. About 1/3 of all accountants are public accountants. They usually specialize in taxes, and they work for themselves or for an acco unting firm. Government accountants maintain and examine the financial records of government agencies and check the record of businesses and individuals whose financial activities are connected with government agencies. Internal auditors review financial records and reports, to judge their reliability. They also review procedures ...

Porter

Michael five forces model Rivalry among competing Firms: this is usually the most powerful of the five competitive forces. The strategies pursued by one firm can be successful only to the extent that they provide competitive advantage over the strategies of other firms (Grobler 2009) ? Due to China’s incredibly high FDI rate, more and more companies are investing into Chinese businesses and strengthening them in both their domestic markets and also on the global front. With the ever increasing growth of their domestic markets it will only be a short while before they become the dominant market leader, if in this span of 30 years they could rise from nothing to 4th largest in the world then it shows what impact they really had and still have on the global economy. Potential entry of new competitors: whenever new firms can easily enter a particular industry, the intensity of competitiveness among firm’s increases. ?When new firms become strengthened through investments, they become direct competitors of the leaders in that industry. . g. A new Chinese innovation in the television industry grows rapidly, they will be direct competitors against any television firms based in China, for example LG and Sony Bargaining power of consumers: when consumers are concentrated, large or buy in volume their bargaining power represents a major force affecting intensity of competition in an industry (Grobler 2009) ? This goes for actual customers(public) and b2b businesses, because those that buy the larger quantities would get the cheaper rates no doubt, however in China how will that be decided? Will it be their size, market share, sales or Return on capital employed. Potential development of substitute products: in many industries firms are in close competition with producers of substitute products in other industries. ?As mentioned throughout this article, the Chinese have the ability to imitate anything, this factor will never disappear especially if Chinese firms enter European or American markets, how those manufacturers would react to the Chinese developments are unimaginable. Bargaining power of suppliers: the bargaining power of suppliers affects the intensity of completion in an industry, especially when there are large number of suppliers, when there are only a few good substitutes’ raw materials or when cost of switching materials is especially costly (Grobler 2009) Porter’s five forces will only be effective if it is done in a stable environment, it is done to see how attractive the industry is and if it is worth starting a new venture in that environment. Porter’s generic strategies †¢Cost leadership †¢Differentiation †¢Focus Cost leadership: Cost leadership means having the lowest per-unit (i. . , average) cost in the industry that is, lowest cost relative to your rivals. This could mean having the lowest per unit cost among rivals in highly competitive industries, in which case returns or profits will be low but however higher than competitors Or, this could mean having lowest cost among a few rivals where each firm enjoys pricing power and high profits Notice that cost leadership is defined independently of market structure. Differentiation: Differentiating the product offering of a firm means creating something that is perceived industry wide as being unique. It is a means of creating your own market to some extent. There are several approaches to differentiation: †¢Different design †¢Brand image †¢Number of features †¢New technology A differentiation strategy may mean differentiating along 2 or more of these dimensions. Focus: Here we focus on a particular buyer group, product segment, or geographical market. while low cost and differentiation are aimed at achieving their objectives industry wide, the focus or niche strategy is built on serving a particular target (customer, product, or location) very well. Note, however, hat a focus strategy means achieving either a low cost advantage or differentiation in a narrow part of the market. For reasons discussed above, this creates a defendable position within that part of the market. Risks of doing generic strategies Cost leadership †¢Requires continual capital investment because newer innovations cause older creations to become obsolete. †¢When focusing solely on making affordable low cost products, it can cause firms to be blinded to product changes that are needed. Ie. Quantity over quality †¢When costs do begin to increase it narrows the differences between competitors and advantage is ultimately lost For China, the main risk that would affect them the most is when focusing solely on quantity, especially because of their expertise in manufacturing they could lose sight of changes that need to be done to better sales. However, China does have the leading number of R&D departments, even though they might not be as innovative as the Japanese or South Koreans, they have the ability to imitate anything they produce which is why they play a major role in globalization, they can imitate anything except fresh air as they say. Differentiation Customer loyalty becomes too large to hold because of the cost differentiation between low cost firms and differentiating firms. †¢The consumer or buyer’s need to differentiate falls away because of price increases. †¢Imitation decreases perceived differentiation This area is where China are dominant, because they have the influence of causing differentiation to fail, because if the product looks the same, and does the same thing, the n why would they ever go for the more expensive, and thus Chinese markets prosper because economies of scale have brought their price down dramatically. This is also when manufacturers have to start looking for alternative suppliers because they now have to compete with China which is not an easy task, and in doing so, it almost definitely forces them to go global. Focus †¢When companies market to niches only they already take the risk of not completely satisfying a demographic segment and with other companies finding alternatives ways to better their market share eg. FDI or R&D labs, they face the risk of dissolving. On its own focus strategy’s should not be attempted by almost any kind of company, its main purpose is to satisfy a small group of consumers at a time, and if this is not the aim of the business then they are going to fall extremely short on their company vision. Books Grobler, W. (2009) Business strategy, CTI Education Group, Johannesburg. Johnson, G. scholes, K. Whittington, R. (2008) Exploring corporate strategy, Prentice Hall, Upper Saddle River.